Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus.

نویسندگان

  • Rita Czakó
  • Robert L Atmar
  • Antone R Opekun
  • Mark A Gilger
  • David Y Graham
  • Mary K Estes
چکیده

A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 19 2  شماره 

صفحات  -

تاریخ انتشار 2012